4-Chlorobenzoyl chloride → HCID 45141326, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 4-chlorobenzoyl chloride to afford the title compound (11 mg, 15%). 1H-NMR (δ, ppm, DMSO-d6): 6.49 (d, 1H, HPy,5, J=6.0 Hz), 6.91 (d, 1H, Harom, J=8.0 Hz), 7.42 (t, 1H, Harom, J=8.0 Hz), 7.59-7.63 (m, 3H, Harom), 7.65 (d, 1H, Harom, J=8.0 Hz), 7.80 (d, 1H, HPy,6, J=6.0 Hz), 7.96 (d, 2H, Harom, J=9.0 Hz), 10.40 (s, 1H, NHamide), 11.19 (s, 1H, NHPy3), 11.38 (s, 1H, NHPy2). HRMS (EI): m/z [M+H] calcd for C19H14N4O3Cl: 381.0754; found: 381.0753.

Provenance & Evidence