Phenylacetyl chloride → HCID 45141324, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 2-phenylacetyl chloride to afford the title compound (11 mg, 15%). 1H-NMR (δ, ppm, DMSO-d6): 3.62 (s, 2H, CH2), 6.45 (d, 1H, HPy,5, J=6.0 Hz), 6.83 (d, 1H, Harom, J=8.0 Hz), 7.22-7.47 (m, 8H, Harom), 7.78 (d, 1H, HPy,6, J=6.0 Hz), 10.28 (s, 1H, NHamide), 11.15 (s, 1H, NHPy3), 11.37 (s, 1H, NHPy2). HRMS (EI): m/z [M+H] calcd for C20H17N4O3: 361.1301; found: 361.1299.

Provenance & Evidence