Benzenepropanoyl chloride → HCID 45141325, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 3-phenylpropanoyl chloride to afford the title compound (15 mg, 19%). 1H-NMR (δ, ppm, DMSO-d6): 2.61 (t, 2H, CH2, J=8.0 Hz), 2.89 (t, 2H, CH2, J=8.0 Hz), 6.45 (d, 1H, HPy,5, J=6.0 Hz), 6.82 (d, 1H, Harom, J=8.0 Hz), 7.16-7.44 (m, 8H, Harom), 7.79 (d, 1H, HPy,6, J=6.0 Hz), 10.02 (s, 1H, NHamide), 11.16 (s, 1H, NHPy3), 11.37 (s, 1H, NHPy2). HRMS (EI): m/z[M+H] calcd for C21H19N4O3: 375.1457; found: 375.1469.

Provenance & Evidence