7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one → HCID 45141329, compound

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Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]-pyridin-2(3H)-one and 2-(3-trifluoromethoxyphenyl)-acetyl chloride to afford the title compound (22 mg, 23.5%). 1H-NMR (δ, ppm, DMSO-d6): 3.71 (s, 2H, CH2), 6.43 (d, 1H, HPy,5, J=5.9 Hz), 6.83-6.86 (m, 1H, Harom), 7.24-7.47 (m, 8H, Harom), 7.78 (d, 1H, HPy,6, J=5.9 Hz), 10.37 (s, 1H, NHamide), 11.21 (s, 1H, NHPy7), 11.42 (s, 1H, NHPy9). LC-MS, tR=4.65 minutes, m/z: 445.04 (M+H)+, calculated for C21H16N4O4F3. HRMS (EI): m/z [M+H] calculated for C21H16N4O4F3: 445.1124; found: 445.1107.

Provenance & Evidence