7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one → HCID 86637551, compound

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Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 3-trifluoromethylthio-benzoyl chloride to afford the title compound (16 mg, 17.0%). 1H-NMR (δ, ppm, DMSO-d6): 6.49 (d, 1H, HPy,5, J=5.9 Hz), 6.93 (ddd, 1H, Harom, J=0.6 Hz, J=2.4 Hz, J=8.2 Hz), 7.44 (t, 1H, Harom, J=8.2 Hz), 7.62 (t, 1H, Harom, J=2.1 Hz), 7.66 (dd, 1H, Harom, J=1.1 Hz, J=8.2 Hz), 7.71 (t, 1H, Harom, J=7.8 Hz), 7.81 (d, 1H, HPy,6, J=5.9 Hz), 7.94 (d, 1H, Harom, J=7.8 Hz), 8.16 (m, 1H, Harom), 8.26 (s, 1H, Harom), 10.50 (s, 1H, NHamide), 11.19 (s, 1H, NHPy7), 11.39 (s, 1H, NHPy9). LC-MS, tR=4.87 minutes, m/z: 447.07 (M+H)+, calculated for C20H14N4O3SF3. HRMS (EI): m/z [M+H] calculated for C20H14N4O3SF3: 447.0739; found: 447.0743.

Provenance & Evidence