2-Fluoro-5-(trifluoromethoxy)benzoyl chloride → HCID 45141563, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 2-fluoro-5-trifluoromethoxy-benzoyl chloride to afford the title compound (11 mg, 11.7%). 1H-NMR (δ, ppm, DMSO-d6): 6.50 (d, 1H, HPy,5, J=5.9 Hz), 6.91-6.94 (m, 1H, Harom), 7.41-7.44 (m, 2H, Harom), 7.50-7.53 (m, 2H, Harom), 7.67-7.69 (m, 1H, Harom), 7.81 (d, 1H, HPy,6, J=5.9 Hz), 10.65 (s, 1H, NHamide), 11.18 (s, 1H, NHPy7), 11.39 (s, 1H, NHPy9). LC-MS, tR=4.65 minutes, m/z: 449.08 (M+H)+, calculated for C20H13N4O4F4. HRMS (EI): m/z [M+H] calculated for C20H13N4O4F4: 449.0873; found: 449.0873.

Provenance & Evidence