Reaction Steps
Method H was used Method H was used with 7-(3-Aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 3-tert-butylbenzoyl chloride to afford the title compound as a light pink solid (90 mg, 54%). 1H-NMR (δ, ppm, DMSO-d6): 1.32 (s, 9H, tBu), 6.49 (d, 1H, HPy,5, J=5.9 Hz), 6.91 (d, 1H, Harom, J=6.7 Hz), 7.41-7.46 (m, 2H, Harom), 7.62-7.66 (m, 3H, Harom), 7.75 (d, 1H, Harom, J=7.6 Hz), 7.81 (d, 1H, HPy,6, J=5.9 Hz), 7.89 (s, 1H, Harom,), 10.35 (s, 1H, NHamide), 11.26 (s, 1H, NHurea), 11.44 (s, 1H, NHurea). 13C-NMR (δ, ppm, DMSO-d6): 30.98 (C(CH3)3), 34.55 (C(CH3)3), 106.41, 110.83, 113.60, 114.40, 116.31, 124.30, 124.78, 128.09, 128.67, 130.11, 134.42, 140.84, 141.31, 144.67, 147.06, 150.90, 154.17, 154.58, 166.06. HRMS (EI): m/z [M+H] calculated for C23H22N4O3: 403.1765; found: 403.1762.
