Reaction Steps
Method Method H2 was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 2-thiomorpholinoisonicotinic acid to afford the title compound as a light pink solid (93 mg, 50%). 1H-NMR (δ, ppm, DMSO-d6): 2.62 (d, 4H, HThiomorph, J=7.2 Hz), 3.96 (d, 4H, HThiomorph, J=7.2 Hz), 6.49 (d, 1H, HPy,5, J=5.9 Hz), 6.93 (dd, 1H, Harom, J=7.9 Hz, J=1.8 Hz), 7.01 (d, 1H, Harom, J=5.1 Hz), 7.19 (s, 1H, Harom), 7.43 (t, 1H, Harom, J=8.2 Hz), 7.60-7.64 (m, 2H, Harom), 7.81 (d, 1H, HPy,6, J=5.9 Hz), 8.25 (d, 1H, Harom, J=5.1 Hz), 10.39 (s, 1H, NHamide), 11.19 (s, 1H, NHurea), 11.39 (s, 1H, NHurea). 13C-NMR (δ, ppm, DMSO-d6): 25.18 (CThiomorph), 47.14 (CThiomorph), 105.01, 106.50, 110.05, 110.75, 113.67, 114.63, 116.26, 130.08, 140.24, 141.28, 143.63, 144.42, 147.04, 148.30, 154.08, 154.64, 158.13, 164.81. HRMS (EI): m/z [M+H] calculated for C22H20N6O3S: 449.1390, found: 449.1396.
