3-(Trifluoromethoxy)benzoyl chloride → HCID 45140541, compound

Participants

Reaction Steps

Method H was used with 4-(5-amino-2,4-difluorophenoxy)-3-nitropyridin-2-amine and 3-(trifluoromethoxy)benzoyl chloride to afford the title compound as a yellow solid (0.33 g, 88%). 1H NMR δ (DMSO): 6.09 (d, 1H, Hpy,5, J=5.5 Hz), 7.26 (bs, 2H, NH2), 7.7 (m, 3H, Harom), 7.90 (s, 1H, Harom,2′), 8.0 (d, 1H, Harom), 8.06 (d, 1H, Hpy,6, J=5.5 Hz), 10.4 (bs, 1H, NHamide). 19F NMR δ (DMSO): −56.78 (s, 1F, CF3), −118.54 (s, 1F, aromF), −129.58 (s, 1F, aromF).

Provenance & Evidence