3-(Trifluoromethoxy)benzoyl chloride → HCID 45140730, compound

Participants

Reaction Steps

Method H was used with 4-(5-amino-2,3,4-trifluorophenoxy)-3-nitropyridin-2-amine and 3-(trifluoromethoxy)benzoyl chloride to afford the title compound (140 mg, 57%). 1H NMR δ (DMSO): 6.26 (d, 1H, Hpy,5, J=5.5 Hz), 7.35 (s, 2H, NH2), 7.55 (t, 1H, Harom,6′, J=6.5 Hz), 7.66 (d, 1H, Harom), 7.71 (t, 1H, Harom,5″, J=8.0 Hz), 7.91 (s, 1H, Harom,2″), 8.00 (d, 1H, Harom), 8.08 (d, 1H, HPy,6, J=5.5 Hz), 10.63 (s, 1H, NHamide). 19F NMR δ (DMSO): −56.28 (s, 3F, CF3), −141.42 (d, 1F, aromF, J=21.5 Hz), −152.31 (d, 1F, aromF, J=21.5 Hz), −156.04 (t, 1F, F3, J=21.5 Hz).

Provenance & Evidence