3-(Trifluoromethoxy)benzoyl chloride → HCID 45140537, compound

Participants

Reaction Steps

Method H was used with 4-(3-Amino-5-chlorophenoxy)-3-nitropyridin-2-amine and 3-(trifluoromethoxy)benzoyl chloride to afford the title compound as a yellow solid (0.155 g, 74%). 1H NMR δ (DMSO): 6.21 (d, 1H, Hpy,5, J=5.5 Hz), 7.13 (t, 1H, Harom, J=2 Hz), 7.25 (s, 2H, NH2), 7.58 (t, 1H, Harom, J=2 Hz), 7.63 (dt, 1H, Harom, J=1+8 Hz), 7.70 (t, 1H, Harom,5, J=8 Hz), 7.86 (d, 1H, Harom, J=2 Hz), 7.89 (s, 1H, Harom,2′), 8.02 (dt, 1H, Harom, J=1+8 Hz), 8.09 (d, 1H, Hpy,6, J=5.5 Hz), 10.6 (s, 1H, NHamide). 19F NMR 6 (DMSO): −56.77 (s, 3F, CF3). MS m/z 469/71(M++1).

Provenance & Evidence