Ethanol hydrochloride → 4-Propyl-1,1-bis(trifluoromethyl)-1,3-dihydroisobenzofuran-5-ol

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Reaction Steps

To 5-(methoxymethoxy)-4-propyl-1,1-bis(trifluoromethyl)-1,3-dihydroisobenzofuran (1.12 g, 3.13 mmol), hydrochloric acid-ethanol (2 mol/L, 5 mL) was added and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated under vacuum. The obtained residue was purified by silica-gel column chromatography (hexane/ethyl acetate) and of the title compound (952.6 mg, 96%) was obtained as colorless crystalline powder.

Provenance & Evidence