m-Chloroperbenzoic acid → HCID 67163938, compound

Participants

Reaction Steps

To a solution of 1.50 g (8.0 mmol) of 4-(4-Fluoro-phenyl)-2-methyl-pyridine in 25 ml of methylene chloride were added 5.93 g (24 mmol, 3.0 equiv.) of 70% m-Chloroperbenzoic acid. The reaction was stirred for 6 h at room temperature. The reaction was worked up with 50 ml 5% sodium bicarbonate solution. The aqueous phase was extracted twice with 40 ml of methylene chloride. The combined organic phases were washed with 30 ml of brine, dried over magnesium sulfate, and concentrated in vaccuo to yield 3.3 g of a yellow oil which was purified by flash chromatography (ethyl acetate/methanol 9:1) to yield the title compound (1.31 g, 80%) as a crystalline light brown solid, MS (ISP): m/e=204.1 (M+H)+.

Provenance & Evidence