3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 24820861, compound

HRID 552497Notes

Reaction equation

HRID 552497 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([CH3:16])=[C:14](Br)[CH:13]=[C:12]([CH3:18])[N:11]=2)=[O:9])[S:5][CH:6]=1.[Cl:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][C:25]=1[F:26]>>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([CH3:16])=[C:14]([C:22]3[CH:23]=[CH:24][C:25]([F:26])=[C:20]([Cl:19])[CH:21]=3)[CH:13]=[C:12]([CH3:18])[N:11]=2)=[O:9])[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 86614582HCID 86614582, compound

Product 1

HCID 24820861HCID 24820861, compound

Procedure

The title compound, was prepared from 4-Bromo-3,6-dimethyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide and 3-Chloro-4-fluorophenylboronic acid in accordance with the general method of example 1, step 6 to yield the final compound as a light yellow solid, MS (ISP): m/e=376.2, 378.2 (M+H)+.

Sources & evidence

ORD record
ord-b19cd1e036074bff8eb09eb3ae4b2b52
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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