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4-Bromo-6-methyl-pyridine-2-carbonitrile → 6'-Cyano-6,2'-dimethyl-[4,4']bipyridinyl-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-6-methyl-pyridine-2-carbonitrile | HCID 53485294 | — |
| 反応物 | 6-Methyl-N-(2-methyl-4-pyridinyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarboxamide | HCID 67164968 | — |
| 生成物 | 6'-Cyano-6,2'-dimethyl-[4,4']bipyridinyl-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide | HCID 67163934 | — |
反応手順
The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide in accordance with the general method of example 131, step 2 using 4-Bromo-6-methyl-pyridine-2-carbonitrile instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a off-white solid, MS (ISP): m/e=344.2 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07951824B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-215906fa18d84a75a2138113a25cc5c8 |
| 出典メモ | uspto-grants-2011_05 |