4-Bromo-2-chloropyridine → HCID 86614583, compound

HRID 552510Notes

Reaction equation

HRID 552510 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15](B3OC(C)(C)C(C)(C)O3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.[Cl:27][C:28]1[CH:33]=[C:32](Br)[CH:31]=[CH:30][N:29]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([C:32]3[CH:31]=[CH:30][N:29]=[C:28]([Cl:27])[CH:33]=3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 38477704-Bromo-2-chloropyridineHCID 671649686-Methyl-N-(2-Methylpyridin-4-yl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide

Product 1

HCID 86614583HCID 86614583, compound

Procedure

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide in accordance with the general method of example 131, step 2 using 2-Chloro-4-bromopyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a white amorphous, MS (ISP): m/e=339.1, 341.1 (M+H)+.

Sources & evidence

ORD record
ord-f59e2037a5a846f98af7d75f35fd3dcd
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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