HCID 18689751, compound → HCID 24820901, compound

HRID 552524Notes

Reaction equation

HRID 552524 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[S:23][CH:24]=[C:25]([CH2:27][C:28]#[N:29])[N:26]=1>>[C:28]([CH2:27][C:25]1[N:26]=[C:22]([NH:21][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[S:23][CH:24]=1)#[N:29]

Participants

3

Reactant 2

HCID 18689751HCID 18689751, compoundHCID 671639994-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 24820901HCID 24820901, compound

Procedure

The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using (2-Amino-thiazol-4-yl)-acetonitrile instead of 3-chloroaniline to yield the final compound as a off-white solid, MS (ISP): m/e=371.2 (M+H)+.

Sources & evidence

ORD record
ord-5bcf35355aa043eca63467b12e7bec77
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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