HCID 45121650, compound → HCID 24820902, compound

HRID 552525Notes

Reaction equation

HRID 552525 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[F:21][CH:22]([F:29])[C:23]1[N:24]=[C:25]([NH2:28])[S:26][CH:27]=1>>[F:21][CH:22]([F:29])[C:23]1[N:24]=[C:25]([NH:28][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[S:26][CH:27]=1

Participants

3

Reactant 2

HCID 45121650HCID 45121650, compoundHCID 671639994-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 24820902HCID 24820902, compound

Procedure

The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 4-Difluoromethyl-thiazol-2-ylamine instead of 3-chloroaniline to yield the final compound as a white solid, MS (ISP): m/e=382 [M]+.

Sources & evidence

ORD record
ord-481fe5c6f9f84994a860179fdbc6222b
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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