2-Amino-4-cyanothiazole → HCID 24820903, compound

HRID 552526Notes

Reaction equation

HRID 552526 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[S:23][CH:24]=[C:25]([C:27]#[N:28])[N:26]=1>>[C:27]([C:25]1[N:26]=[C:22]([NH:21][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[S:23][CH:24]=1)#[N:28]

Participants

3

Reactant 2

HCID 50841832-Amino-4-cyanothiazoleHCID 671639994-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 24820903HCID 24820903, compound

Procedure

The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 2-Amino-4-thiazolecarbonitrile instead of 3-chloroaniline to yield the final compound as a off-white solid, MS (ISP): m/e=356.9 (M+H)+.

Sources & evidence

ORD record
ord-38a112b510414258b2fe421ad3ad407e
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

Loading…