4-(Methoxymethyl)-1,3-thiazol-2-amine → 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide

HRID 552527Notes

Reaction equation

HRID 552527 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[CH3:21][O:22][CH2:23][C:24]1[N:25]=[C:26]([NH2:29])[S:27][CH:28]=1>>[CH3:21][O:22][CH2:23][C:24]1[N:25]=[C:26]([NH:29][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[S:27][CH:28]=1

Participants

3

Reactant 2

HCID 230925274-(Methoxymethyl)-1,3-thiazol-2-amineHCID 671639994-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 248209044-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide

Procedure

The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 4-Methoxymethyl-thiazol-2-ylamine (CAS: [640768-40-7]) instead of 3-chloro-aniline to yield the final compound as a light brown solid, MS (ISP): m/e=376.3 (M+H)+.

Sources & evidence

ORD record
ord-9af0ac43bad440109c818e377e93fd04
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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