Ethyl 4-bromo-6-methylpicolinate → 5-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10](Br)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2].[F:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[N:19][CH:20]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10]([C:17]2[CH:18]=[N:19][CH:20]=[C:15]([F:14])[CH:16]=2)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2]Participants
3
Procedure
The title compound, was prepared from 4-Bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester (example 1, step 4) and 5-Fluoropyridine-3-boronic acid in accordance with the general method of example 1, step 6 to yield the final compound as a light yellow oil, MS (ISP): m/e=261.2 (M+H)+.
Sources & evidence
- ORD record
- ord-5033bb24425e4c80b45c40155b35b70c
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07951824B2
Reaction notes
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