HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-1,3-thiazol-2-amine → 4-(3,5-Difluoro-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-fluoro-thiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-1,3-thiazol-2-amine | HCID 10080385 | — |
| Reactant | 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester | HCID 67163999 | — |
| Product | 4-(3,5-Difluoro-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-fluoro-thiazol-2-yl)-amide | HCID 86614595 | — |
Reaction Steps
The title compound, was prepared from 4-(3,5-Difluoro-phenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 5-Fluoro-thiazol-2-ylamine (CAS: [64588-82-5], WO2006016178 instead of 3-Chloroaniline to yield the final compound as a light yellow crystalline solid, MS (ISP): m/e=350.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951824B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-d266e068f9754905b119606862949983 |
| Source note | uspto-grants-2011_05 |