4-(Methoxymethyl)-1,3-thiazol-2-amine → 5-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide

HRID 552549Notes

Reaction equation

HRID 552549 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[CH3:20][O:21][CH2:22][C:23]1[N:24]=[C:25]([NH2:28])[S:26][CH:27]=1>>[CH3:20][O:21][CH2:22][C:23]1[N:24]=[C:25]([NH:28][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])[S:26][CH:27]=1

Participants

3

Reactant 2

HCID 230925274-(Methoxymethyl)-1,3-thiazol-2-amineHCID 671647705-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester

Product 1

HCID 866145965-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide

Procedure

The title compound, was prepared from 5-Fluoro-6′-methyl-[3,4′]bipyridinyl-2′-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 4-Methoxymethyl-thiazol-2-ylamine instead of 3-Chloroaniline to yield the final compound as a off-white solid, MS (ISP): m/e=359.1 (M+H)+.

Sources & evidence

ORD record
ord-3a413bd40f534e1d96e3971001bb09d2
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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