HCID 18689751, compound → HCID 86614597, compound

HRID 552550Notes

Reaction equation

HRID 552550 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[S:22][CH:23]=[C:24]([CH2:26][C:27]#[N:28])[N:25]=1>>[C:27]([CH2:26][C:24]1[N:25]=[C:21]([NH:20][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])[S:22][CH:23]=1)#[N:28]

Participants

3

Reactant 2

HCID 18689751HCID 18689751, compoundHCID 671647705-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester

Product 1

HCID 86614597HCID 86614597, compound

Procedure

The title compound, was prepared from 5-Fluoro-6′-methyl-[3,4′]bipyridinyl-2′-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using (2-Amino-thiazol-4-yl)-acetonitrile instead of 3-Chloroaniline to yield the final compound as a light yellow solid, MS (ISP): m/e=354.1 (M+H)+.

Sources & evidence

ORD record
ord-01c14c480f9c40ca9ff3d435d77d19c5
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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