5-Fluoro-1,3-thiazol-2-amine → HCID 86614598, compound

HRID 552551Notes

Reaction equation

HRID 552551 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[F:20][C:21]1[S:25][C:24]([NH2:26])=[N:23][CH:22]=1>>[F:20][C:21]1[S:25][C:24]([NH:26][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])=[N:23][CH:22]=1

Participants

3

Reactant 2

HCID 100803855-Fluoro-1,3-thiazol-2-amineHCID 671647705-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester

Product 1

HCID 86614598HCID 86614598, compound

Procedure

The title compound, was prepared from 5-Fluoro-6′-methyl-[3,4′]bipyridinyl-2′-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 5-Fluoro-thiazol-2-ylamine instead of 3-Chloroaniline to yield the final compound as a light yellow crystalline solid, MS (ISP): m/e=333.1 (M+H)+.

Sources & evidence

ORD record
ord-eb2a3c45c90b4d70bb120a0e93bb062d
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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