HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-hydroxybenzoic Acid → (2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-hydroxybenzoic Acid | HCID 2783398 | — |
| Reactant | (R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine | HCID 46911921 | — |
| Product | (2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone | HCID 11960537 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure D from 2-fluoro-4-hydroxy-benzoic acid and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine (Intermediate 11). MS (ES+) 307.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951826B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-46b637ba78b54c21b8c54367754621da |
| Source note | uspto-grants-2011_05 |