{2-[(Methanesulfonyl)amino]phenyl}boronic acid → HCID 58381140, compound

HRID 552595Notes

Reaction equation

Br[C:2]1[CH:23]=[CH:22][C:5]2[N:6]([CH3:21])[C:7](/[CH:9]=[CH:10]/[C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)=[N:8][C:4]=2[CH:3]=1.BrC1C=CC2N=C(/C=C/C3C=CC(C(F)(F)F)=CC=3)N(C)C=2C=1.[CH3:47][S:48]([NH:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=1B(O)O)(=[O:50])=[O:49]>>[CH3:21][N:6]1[C:5]2[CH:22]=[C:23]([C:53]3[CH:54]=[CH:55][CH:56]=[CH:57][C:52]=3[NH:51][S:48]([CH3:47])(=[O:50])=[O:49])[CH:2]=[CH:3][C:4]=2[N:8]=[C:7]1/[CH:9]=[CH:10]/[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=1

Participants

Reactant 3

HCID 2773533{2-[(Methanesulfonyl)amino]phenyl}boronic acid

HCID 67164788HCID 67164788, compound

HCID 67165229HCID 67165229, compound

Product 1

HCID 58381140HCID 58381140, compound

Procedure

Using the procedure of Example 1, Step B, the title compounds were prepared from a mixture of (E)-5-bromo-1-methyl-2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benzimidazole and (E)-6-bromo-1-methyl-2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benzimidazole and 2-methylsulfonylaminophenyl boronic acid.

Sources & evidence

ORD record: ord-e2e53584b4244558be9037ad58ff45d3
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07951829B2

Reaction notes

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