HRID55266

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11275159

Methyl 3-ethynylbenzoate

C10H8O2

结构：COC(=O)CCc1nc(I)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID86750763

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1nc(C#Cc2cccc(C(=O)OC)c2)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID67703751

未命名化合物

收率 79.2%

PROCEDURE

实验过程

Under the conditions of example 5 A, 1 g of 3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester is reacted with 320 mg of 3-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-15% ethyl acetate. 835 mg of 3-{6-[2-(3-methoxycarbonylphenyl)-ethinyl]-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester is obtained as oil.

WORKUP

后处理

customthe crude product is chromatographed on silica gel with hexane/0-15% ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-134af14b902046eb9036ffa2c7d92eef
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05624943
来源说明: uspto-grants-1997_04

反应 SMILES

[CH3:1][O:2][C:3](=[O:28])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[CH:10][CH:9]=[C:8](I)[N:7]=1.[CH3:29][O:30][C:31](=[O:40])[C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]#[CH:39])[CH:33]=1>>[CH3:1][O:2][C:3](=[O:28])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[CH:10][CH:9]=[C:8]([C:39]#[C:38][C:34]2[CH:35]=[CH:36][CH:37]=[C:32]([C:31]([O:30][CH3:29])=[O:40])[CH:33]=2)[N:7]=1