Acetic Acid → HCID 131728933, compound

HRID 552682Notes

Reaction equation

HRID 552682 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH2:9]1)C1C=CC=CC=1.[C:24]([OH:27])(=[O:26])[CH3:25]>>[F:23][C:20]([F:21])([F:22])[C:17]1[CH:18]=[CH:19][C:14]([CH2:13][CH:10]2[CH2:11][CH2:12][N:8]([CH2:25][C:24]([OH:27])=[O:26])[CH2:9]2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 67171204HCID 67171204, compound

Product 1

HCID 131728933HCID 131728933, compound

Procedure

Prepared in analogy to Example A1(d) from 1-Benzyl-3-(4-trifluoromethyl-benzyl)-pyrrolidine (CAS: 336182-64-0) by replacing HCl with acetic acid to yield the title compound as an light brown oil. MS (m/e): 230.4 (M+H+, 100%).

Sources & evidence

ORD record
ord-520921212148464c9cf08c6ce8ccf789
Source dataset
uspto-grants-2011_05
Patent number
US07951836B2

Reaction notes

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