4-Hydroxypyrrolidine → HCID 59030473, compound

HRID 552689Notes

Reaction equation

HRID 552689 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][C@@H:15]([CH3:20])[C:16]([F:19])([F:18])[F:17])=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].[NH:21]1[CH2:25][CH2:24][CH:23]([OH:26])[CH2:22]1>>[OH:26][CH:23]1[CH2:24][CH2:25][N:21]([C:10]([C:9]2[CH:13]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=[CH:7][C:8]=2[O:14][C@@H:15]([CH3:20])[C:16]([F:19])([F:18])[F:17])=[O:12])[CH2:22]1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 58863351(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid

Product 1

HCID 59030473HCID 59030473, compound

Procedure

Prepared in analogy to Example C1 from 5-Methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (CAS: 845616-82-2) and rac-3-pyrrolidinol. The crude material was crystallized with dichoromethane to provide the title compound as white solid. MS (m/e): 382.3 (M+H+, 100%).

Workup

  1. customThe crude material was crystallized with dichoromethane

Sources & evidence

ORD record
ord-2090486d84514aa9a86d49d24a268f52
Source dataset
uspto-grants-2011_05
Patent number
US07951836B2

Reaction notes

Loading…