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HRID552694

反应详情

EQUATION

反应方程式

HRID 552694 的结构方程式

REACTANTS

反应物

2
结构：NS(=O)(=O)Cl
HCID24499

Amidosulfonic acid chloride

H2ClNO2S

结构：CC(=O)O[C@H]1C[C@H](n2cnc3c(N[C@H]4CCc5ccccc54)ncnc32)O[C@@H]1CO
HCID67164798

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@H]1C[C@H](n2cnc3c(N[C@H]4CCc5ccccc54)ncnc32)O[C@@H]1COS(N)(=O)=O
HCID86607295

未命名化合物

收率 74%

PROCEDURE

实验过程

(2R,3S,5R)-5-{6-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-9H-purin-9-yl}-2-(hydroxymethyl)tetrahydrofuran-3-yl acetate (199 mg, 0.29 mmol) was treated with chlorosulfonamide as described in Example 39, step c. The product was purified by flash chromatography (0 to 5% MeOH/CH2Cl2) to afford 105 mg (74%) of the title compound.

WORKUP

后处理

  1. customThe product was purified by flash chromatography (0 to 5% MeOH/CH2Cl2)