反应详情

Under the conditions of example 5 A, 500 mg of 3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester is reacted with 102 mg of phenylacetylene, worked up, and the crude product is chromatographed on silica gel with hexane/0-7% ethyl acetate. 265 mg of 3-{3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-6-(2-phenylethinyl)-2-pyridyl}-propionic acid methyl ester is obtained as oil.

1. customthe crude product is chromatographed on silica gel with hexane/0-7% ethyl acetate