HRID552747

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)O[C@@H]2[C@H](O1)[C@@H](COS(N)(=O)=O)O[C@H]2n1cnc2c(C#Cc3ccccc3C(F)(F)F)ncnc21

HCID86607327

未命名化合物

PRODUCTS

生成物

结构：NS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(C#Cc4ccccc4C(F)(F)F)ncnc32)[C@H](O)[C@@H]1O

HCID58296166

未命名化合物

收率 52%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22392675

未命名化合物

PROCEDURE

实验过程

[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-{[2-(trifluoromethyl)phenyl]ethynyl}-9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl sulfamate (0.185 g, 0.343 mmol) was stirred in 3 mL of 90% TFA/H2O for 4 h at r.t. The solvent was removed and the crude product was purified by flash chromatography (1 to 10% MeOH/CH2Cl2) to isolate the title compound (0.0882 g, 52%).

WORKUP

后处理

customThe solvent was removed
customthe crude product was purified by flash chromatography (1 to 10% MeOH/CH2Cl2)