2-Methoxybenzoyl chloride → HCID 86607336, compound

HRID 552770Notes

Reaction equation

[C:1]([NH:20][S:21](=[O:46])(=[O:45])[O:22][CH2:23][C@@H:24]1[C@@H:31]2[C@@H:27]([O:28][C:29]([CH3:33])([CH3:32])[O:30]2)[C@H:26]([N:34]2[CH:42]=[N:41][C:40]3[C:35]2=[N:36][CH:37]=[N:38][C:39]=3[CH2:43][NH2:44])[O:25]1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:47][O:48][C:49]1[CH:57]=[CH:56][CH:55]=[CH:54][C:50]=1[C:51](Cl)=[O:52]>>[C:1]([NH:20][S:21](=[O:45])(=[O:46])[O:22][CH2:23][C@@H:24]1[C@@H:31]2[C@@H:27]([O:28][C:29]([CH3:33])([CH3:32])[O:30]2)[C@H:26]([N:34]2[CH:42]=[N:41][C:40]3[C:35]2=[N:36][CH:37]=[N:38][C:39]=3[CH2:43][NH:44][C:51](=[O:52])[C:50]2[CH:54]=[CH:55][CH:56]=[CH:57][C:49]=2[O:48][CH3:47])[O:25]1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 889692-Methoxybenzoyl chloride

HCID 86607337HCID 86607337, compound

Product 1

HCID 86607336HCID 86607336, compound

Procedure

The title compound was prepared following the procedure described in Example 127, step a using {(3aR,4R,6R,6aR)-6-[6-(aminomethyl)-9H-purin-9-yl]-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl}methyl tritylsulfamate and 2-methoxybenzoyl chloride.

Sources & evidence

ORD record: ord-015212d13a674691805a7a0d0828d032
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07951810B2

Reaction notes

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