HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → 5-Iodo-4-phenethyl-7H-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | 4-phenethyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 67164919 | — |
| Solvent | 2-Oxopropiononitrile | HCID 69430 | — |
| Product | 5-Iodo-4-phenethyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 67163935 | 83% |
Reaction Steps
To a solution of 4-phenethyl-7H-pyrrolo[2,3-d]pyrimidine (3.15 g, 14.1 mmol) in AcCN was added N-iodosuccinimide and the mixture was stirred at r.t. for 12 hr. The precipitate was collected and recrystallized from MeOH to give the title compound (4.06 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951810B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-e42ee6c2035c44cebf97eba7cb5a59ff |
| Source note | uspto-grants-2011_05 |