4-Iodo-2-(trifluoromethyl)pyridine → (S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoate

Participants

Role	Name	HCID	Charge
Reactant	4-Iodo-2-(trifluoromethyl)pyridine	HCID 23436940	—
Reactant	(R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate	HCID 86614124	—
Product	(S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoate	HCID 67165305	—

Reaction Steps

The title compound was prepared according to previously reported procedure (U.S. patent application Ser. No. 11/575,187) from (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 4-iodo-2-(trifluoromethyl)pyridine (this starting material was prepared according to a procedure described in Eur. J. Org. Chem. 2003, 1559-1568).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07951838B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-fac39114a81e414f8428f995c11ff35d
Source note	uspto-grants-2011_05