HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5RS)-5-hydroxy-5-(2-iodo-3-methoxy-6-pyridyl)-pentanoic acid methyl ester → 5-(2-Iodo-3-methoxy-6-pyridyl)-5-oxopentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5RS)-5-hydroxy-5-(2-iodo-3-methoxy-6-pyridyl)-pentanoic acid methyl ester | HCID 54350032 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Product | 5-(2-Iodo-3-methoxy-6-pyridyl)-5-oxopentanoic acid methyl ester | HCID 53871303 | 43.3% |
Reaction Steps
Under the conditions of example 16 E, 9.98 g of (5RS)-5-hydroxy-5-(2-iodo-3-methoxy-6-pyridyl)-pentanoic acid methyl ester is reacted with 43 g of manganese dioxide for 6 hours, worked up, and the crude product is chromatographed on silica gel with hexane/0-35% ethyl acetate. 4.3 g of 5-(2-iodo-3-methoxy-6-pyridyl)-5-oxopentanoic acid methyl ester of melting point 111° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624943 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-bb22d03db6854794a05e850718407c3c |
| Source note | uspto-grants-1997_04 |