HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetaldehyde → 5-Methylimidazo[1,2-a]pyridine-6-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 6-Amino-2-methylpyridine-3-carbonitrile | HCID 2794662 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Methylimidazo[1,2-a]pyridine-6-carbonitrile hydrochloride | HCID 67163716 | — |
Reaction Steps
To a solution of 6-amino-2-methylnicotinonitrile (960 mg) in ethanol (34 ml) was added a 40% aqueous chloroacetaldehyde solution (2.36 ml) at 60° C. The reaction mixture was refluxed for 8 hours. The resulting precipitates were collected by filtration to obtain 5-methylimidazo[1,2-a]pyridine-6-carbonitrile hydrochloride (580 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951825B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-1dbbd8def99042788ccdb14a16def3dd |
| Source note | uspto-grants-2011_05 |