(1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene → HCID 67703787, compound

Participants

Reaction Steps

Under the conditions of example 1 D, 70 mg of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-5-oxopentanoic acid methyl ester is reacted with 58 mg of (1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene, worked up, and the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate. 52 mg of 5-{2-(2-methoxycarbonylethyl)-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-6-pyridyl}-5-oxopentanoic acid methyl ester is obtained as oil.

Provenance & Evidence