HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl malonate → DIMETHYL 2-(4-CYANO-2-NITROPHENYL)MALONATE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl malonate | HCID 7943 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Fluoro-3-nitrobenzonitrile | HCID 2774654 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | DIMETHYL 2-(4-CYANO-2-NITROPHENYL)MALONATE | HCID 7210838 | 39.4% |
Reaction Steps
To a solution of 4-fluoro-3-nitrobenzonitrile (300 mg) and dimethyl malonate (286 mg) in DMF was added 60% NaH at 0° C., followed by reaction at room temperature to obtain dimethyl (4-cyano-2-nitrophenyl)malonate (198 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951825B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-cdd009e303604a62ac58b20525ca2b3f |
| Source note | uspto-grants-2011_05 |