HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Acrylate → HCID 86750767, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Iodo-5-methoxypicolinaldehyde | HCID 19957454 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86750767 | HCID 86750767 | — |
Reaction Steps
Under the conditions of example 16 H, a solution of 20 g of 2-iodo-3-methoxypyridine-6-aldehyde in 100 ml of dimethylformamide is reacted with 33.5 ml of acrylic acid methyl ester in the presence of 1.73 g of palladium acetate, 26.1 g of potassium carbonate and 23.8 g of tetrabutylammonium bromide, worked up, and the crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate. 11.66 g of 3-(6-formyl-3-methoxy-2-pyridyl)-(2E)-2-propenoic acid methyl ester of melting point 132°-134° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624943 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-341d47c9f25a41fbbd585b6cf73115be |
| Source note | uspto-grants-1997_04 |