Ammonium Chloride → HCID 178466117, compound

Participants

Reaction Steps

To a solution of 5-[3-(1H-benzimidazol-6-yl)-1,2,4-oxadiazol-5-yl]-2-(2,2,2-trifluoro-1-methylethoxy)benzaldehyde (80 mg) in ethanol (3 ml) was added NaBH4 (9 mg) at 0° C. After stirring at room temperature for 0.5 hour, a saturated NH4Cl solution (10 ml) was added thereto, followed by extraction with EtOAc (20 ml). The organic layer was washed with saturated brine, dried over anhydrous MgSO4, and then filtered, and the filtrate was concentrated. To a solution of the residue (78 mg) in dioxane was added a 4M HCl/dioxane solution, followed by concentration. The resulting powder was recrystallized with IPA (10 ml) to obtain [5-[3-(1H-benzimidazol-5-yl)-1,2,4-oxadiazol-5-yl]-2-(2,2,2-trifluoro-1-methylethoxy)phenyl]methanol hydrochloride (70 mg) as white powders.

Provenance & Evidence