反应详情

Under the conditions of example 1 D, 510 mg of 3-(6-formyl-3-hydroxy-2-pyridyl)-propionic acid methyl ester is reacted with 730 mg of (1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene, worked up, and the crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate. 284 mg of 3-{6-formyl-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester of melting point 66°-69° C. is obtained.

1. customthe crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate