HCID 67171740, compound → HCID 72347756, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of {2-allyl-6-[methyl(methylsulfonyl)amino]pyridine-4-yl}methyl 3-allyl-N-(tert-butoxycarbonyl)-α-methylphenylalaninate (80 mg, 0.14 mmol) in degassed DCE (2.9 mL) was added Zhan (metathesis) Catalyst I (9.2 mg, 0.014 mmol). The reaction was heated to 120° C. in a microwave for 0.5 h. Concentration and flash, chromatography (silica gel, 0-50% EtOAc/hexanes) gave tert-butyl [(3EZ)-14-methyl-8-[methyl(methylsulfonyl)amino]-13-oxo-12-oxa-7-azatricyclo[14.3.1.16,10]henicosa-1(20),3,6(21),7,9,16,18-heptaen-14-yl]carbamate. MS: 530.4 (M+1) ES+

Provenance & Evidence