HCID 72347756, compound → HCID 59650935, compound

Participants

Reaction Steps

A solution of tert-butyl [(3EZ)-14-methyl-8-[methyl(methylsulfonyl)amino]-13-oxo-12-oxa-7-azatricyclo[14.3.1.16,10]henicosa-1(20),3,6(21),7,9,16,18-heptaen-14-yl]carbamate (14 mg, 0.026 mmol) (Intermediate V.11.c.1) in DCM (0.5 mL) and TFA (1.5 mL) was stirred at rt for 1 h. Concentration, purification and separation of EZ isomers by reverse phase preparative HPLC (5-95% CH3CN in water containing 0.1% TFA) gave N-[(3E)-14-Amino-14-methyl-13-oxo-12-oxa-7-azatricyclo[14.3.1.16,10]henicosa-1(20),3,6(21),7,9,16,18-heptaen-8-yl]-N-methylmethanesulfonamide and N-[(3Z)-14-Amino-14-methyl-13-oxo-12-oxa-7-azatricyclo[14.3.1.16,10]henicosa-1(20),3,6(21),7,9,16,18-heptaen-8-yl]-N-methylmethanesulfonamide

Provenance & Evidence