HCID 72347756, compound → HCID 86617854, compound

Participants

Reaction Steps

To a solution of tert-butyl [(3EZ)-14-methyl-8-[methyl(methylsulfonyl)amino]-13-oxo-12-oxa-7-azatricyclo[14.3.1.16,10]henicosa-1(20),3,6(21),7,9,16,18-heptaen-14-yl]carbamate (22.5 mg, 0.042 mmol) (Intermediate V.11.c.1) in degassed THF (2.5 mL) was added palladium on carbon (10%, 3 mg). The reaction was stirred under a hydrogen atmosphere (1 atm) for 1 h and filtered through celite. Concentration gave tert-butyl [14-methyl-8-[methyl(methylsulfonyl)amino]-13-oxo-12-oxa-7-azatricyclo[14.3.1.16,10]henicosa-1(20),6(21),7,9,16,18-hexaen-14-yl]carbamate. MS: 532.0 (M+1) ES+

Provenance & Evidence