HCID 57779833, compound → HCID 57779822, compound

Participants

Reaction Steps

40 mg (0.13 mmol) of 5-allyl-4-{allyl[(6-chloropyridin-3-yl)methyl]amino}furan-2(5H)-one (VI-1) are dissolved in 4 ml of dichloromethane, 11 mg (0.013 mmol) of the second generation Grubbs catalyst are added and the mixture is stirred at room temperature for 2 hours. Concentration under reduced pressure and purification of the residue by column chromatography on silica gel (silica gel 60, Merck, particle size: 0.04 to 0.063 mm) using the mobile phase ethyl acetate gives 29 mg (80% of theory) of 4-[(6-chloropyridin-3-yl)methyl]-4,5,8,8a-tetrahydro-2H-furo[3,2-b]azepin-2-one.

Provenance & Evidence