HRID55299

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15472944

未命名化合物

结构：COC(=O)CCc1nc(C#Cc2ccc(CC(=O)OC)cc2)ccc1O

HCID67703739

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1nc(C#Cc2ccc(CC(=O)OC)cc2)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID67703829

未命名化合物

收率 54.8%

PROCEDURE

实验过程

Under the conditions of example 1 D, 600 mg of 3-{3-hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester is reacted with 460 mg of (1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene, worked up, and the crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate. 504 mg of 3-{3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester is obtained as oil.

WORKUP

后处理

customthe crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c52d4b4eca1d46cab6977cba95a46e59
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05624943
来源说明: uspto-grants-1997_04

反应 SMILES

[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]([C:13]#[C:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:17][CH:16]=2)[N:7]=1.Br[CH2:28][CH2:29][CH2:30][CH2:31]/[CH:32]=[CH:33]/[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=1>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:28][CH2:29][CH2:30][CH2:31]/[CH:32]=[CH:33]/[C:34]2[CH:35]=[CH:36][C:37]([O:40][CH3:41])=[CH:38][CH:39]=2)=[CH:10][CH:9]=[C:8]([C:13]#[C:14][C:15]2[CH:16]=[CH:17][C:18]([CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:19][CH:20]=2)[N:7]=1