3-{3-Hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester → 3-{3-Hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethyl]-2-pyridyl}-propionic acid-methyl ester

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Reaction Steps

Under the conditions of example 14 A, a solution of 500 mg of 3-{3-hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid-methyl ester in 5 ml of methanol is hydrogenated in the presence of 50 mg of 10% palladium catalyston activated carbon and worked up. The crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate. 266 mg of 3-{3-hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethyl]-2-pyridyl}-propionic acid-methyl ester of melting point 90°-91° is obtained.

Provenance & Evidence