HRID55303

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID54259246

未命名化合物

结构：COC(=O)CCc1nc(I)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID86750763

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1nc(C#Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID67703720

未命名化合物

收率 30%

PROCEDURE

实验过程

Under the conditions of example 5 A, 1.31 g of the crude N-benzenesulfonyl-4-ethinylbenzoic acid amide is reacted with 1.9 g of 3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with dichloromethane/0-5% methanol. 750 mg of 3-{3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-6-[2-(4-benzenesulfonamidocarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester is obtained as oil.

WORKUP

后处理

customthe crude product is chromatographed on silica gel with dichloromethane/0-5% methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-beb9ae21e7e7406597b47c3add4334d1
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05624943
来源说明: uspto-grants-1997_04

反应 SMILES

[C:1]1([S:7]([NH:10][C:11](=[O:20])[C:12]2[CH:17]=[CH:16][C:15]([C:18]#[CH:19])=[CH:14][CH:13]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][O:22][C:23](=[O:48])[CH2:24][CH2:25][C:26]1[C:31]([O:32][CH2:33][CH2:34][CH2:35][CH2:36]/[CH:37]=[CH:38]/[C:39]2[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][CH:40]=2)=[CH:30][CH:29]=[C:28](I)[N:27]=1>>[CH3:21][O:22][C:23](=[O:48])[CH2:24][CH2:25][C:26]1[C:31]([O:32][CH2:33][CH2:34][CH2:35][CH2:36]/[CH:37]=[CH:38]/[C:39]2[CH:40]=[CH:41][C:42]([O:45][CH3:46])=[CH:43][CH:44]=2)=[CH:30][CH:29]=[C:28]([C:19]#[C:18][C:15]2[CH:14]=[CH:13][C:12]([C:11]([NH:10][S:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)(=[O:8])=[O:9])=[O:20])=[CH:17][CH:16]=2)[N:27]=1